Status:
UNKNOWN
Nasopharyngeal Bacterial Carriage and Antibiotic Resistance in Children With Sickle Cell Disease in Ile-De-France
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Sickle Cell Disease
Eligibility:
All Genders
6-15 years
Phase:
NA
Brief Summary
The objective of this study is to to determine the rate of nasopharyngeal carriage of Streptococcus pneumoniae (Sp) in children with sickle cell disease over 6 months and under 15 years of age over a ...
Detailed Description
Sickle cell disease is the most common genetic disease in France, with one affected child for every 1,736 births. Ile-de-France is the region in Europe with the highest prevalence of sickle cell disea...
Eligibility Criteria
Inclusion
- Children aged 6 months to 15 years, regardless of immunization status.
- Child with a major sickle cell syndrome (SS, SC, S+, S°, SE) followed in one of the centers of competence or reference for rare diseases (CRMR) " Major sickle cell syndromes, Thalassemias and other rare pathologies of the Red Blood Cell and Erythropoiesis " in Ile de France.
- Children who are not subject to legal protection measures.
- Child affiliated to a social security system.
- Signed informed consent
Exclusion
- Sickle cell child with a febrile syndrome at the time of sampling or hospitalized for any reason.
- Child having received antibiotic therapy other than oracillin in the 7 days preceding the nasopharyngeal swab.
- Child already included in the observation period (only 1 nasopharyngeal swab per patient).
- Other hemoglobinopathies and heterozygous AS or AC patients.
- Patients already involved in a therapeutic protocol or in the exclusion period following a previous research.
- Patients under AME or without social security coverage.
Key Trial Info
Start Date :
February 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2023
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT05197205
Start Date
February 1 2022
End Date
February 1 2023
Last Update
January 19 2022
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