Status:
SUSPENDED
Investigating the Anabolic Response to Resistance Exercise During Critical Illness
Lead Sponsor:
Karolinska University Hospital
Conditions:
Critical Illness
Muscle Loss
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
ICU patients often suffer from rapid and severe muscle loss. It is not known if physical therapy can mitigate the muscle wasting associated with critical illness. The aim of this study is to investig...
Detailed Description
Background The debilitating impact of critical illness has been recognized for several decades. Disability related to intensive care is now described as a syndrome called ICU-acquired weakness (ICUAW...
Eligibility Criteria
Inclusion
- Adult (≥18 years) patient admitted to the ICU of the study site.
- Patient deemed suitable for active mobilization by the attending physician and physiotherapist.
- Not expected to be discharged or transferred from the unit within 24 h of enrollment.
- Functioning arterial catheter in situ.
Exclusion
- Not able to provide informed consent.
- Systemic anticoagulation with LMWH/UFH/DOAC in therapeutic dose range for deep vein thrombosis or pulmonary embolism, or dual antiplatelet therapy. If LMWH is administered twice daily, the patient is eligible for participation provided that vascular access is performed at nadir prior to the first daily dose.
- Clinically significant inherited or acquired disorder of hemostasis.
- Morbid obesity that interferes with femoral cannulation or doppler measurements.
- Hemodynamic instability requiring ongoing volume resuscitation with crystalloid solutions or blood products.
- Lower-limb amputee.
- Lower-limb artherosclerotic disease with critical ischemia.
- Metastatic cancer or active hematological malignancy.
- Inherited disorder of amino acid metabolism.
- Chronic muscle, neuromuscular and neurologic disease with prior documentation of clinically significant lower-limb involvement.
- Pregnancy.
- CAM-ICU screening positive for delirium.
- Single organ failure not requiring invasive mechanical ventilation prior to enrollment.
Key Trial Info
Start Date :
December 25 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT05197231
Start Date
December 25 2022
End Date
December 1 2027
Last Update
March 7 2024
Active Locations (1)
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1
Karolinska University Hospital
Huddinge, Stockholm County, Sweden, 14186