Status:
UNKNOWN
Zooming in on Cerebral Abnormalities in Severely Affected COVID-19 Patients
Lead Sponsor:
Maastricht University Medical Center
Conditions:
COVID-19
Intensive Care Unit
Eligibility:
All Genders
18+ years
Brief Summary
Brain injury is one of the complications in COVID-19 intensive care unit (ICU) survivors, though the precise underlying mechanism is unclear. It is likely caused by a combination of prolonged hypoxia,...
Detailed Description
Brain injury is one of the complications in COVID-19 intensive care unit (ICU) survivors, though the precise underlying mechanism is unclear. It is likely caused by a combination of prolonged hypoxia,...
Eligibility Criteria
Inclusion
- Proven COVID-19 infection for which participant was admitted to the ICU for at least 3 days
- Included in the MaastrICCht cohort (a large database of serial measurements collected during ICU stay from patients with COVID-19 admitted to the ICU in the Maastricht University Medical Center+)
- Informed consent is given
- Sufficient command of the Dutch language to follow test instructions and understand the information letter, informed consent, and questionnaires
Exclusion
- Objective cognitive impairments before hospital admission for the COVID-19 infection
- An unexpected incident leading to severe neurological damage after hospital discharge (such as stroke or traumatic brain injury)
- Contra-indications for MRI scanning (e.g. metal implants, cardiac pacemaker, claustrophobia, pregnancy, and tattoos in the head/neck region)
- Unwillingness to be informed about clinical relevant (abnormal) MRI-findings
- Contra-indications for a gadolinium-based MRI contrast agent (known allergy or insufficient kidney function determined by an eGFR \< 30 mL/min)
- Physical inability to travel to one of the locations (e.g. bedridden patients)
Key Trial Info
Start Date :
June 20 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2024
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT05197296
Start Date
June 20 2022
End Date
October 1 2024
Last Update
June 29 2022
Active Locations (1)
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1
Maastricht University Medical Center+
Maastricht, Limburg, Netherlands, 6229HX