Status:
RECRUITING
Association of Intrahepatic Cholestasis of Pregnancy and Chronic Placental Inflammation
Lead Sponsor:
University Hospital, Brest
Conditions:
Cholestasis of Pregnancy
Eligibility:
FEMALE
18-60 years
Brief Summary
This observational prospective study will help to determine if an immune process similar to allograft rejection is responsible for the occurrence of an intrahepatic cholestasis of pregnancy (ICP). If...
Detailed Description
This observational study will include 322 pregnant women at delivery: 161 women diagnosed with an intrahepatic cholestasis of pregnancy, and 161 control women. A blood test will be performed at deliv...
Eligibility Criteria
Inclusion
- Adult pregnant woman with singleton
- For cases: diagnosis of intrahepatic cholestasis of pregnancy For controls: no diagnosis of ICP
Exclusion
- Women under 18 years old
- Women under legal protection
- Gemellar pregnancies
- Delivery before 22 Weeks of gestation
- Medical termination of pregnancy
- Acute chorioamniotitis, in particular those due to the following pathogens: toxoplasmosis, rubella, CMV, herpes virus
- Premature rupture of membranes \<37SA
- Women infected by covid-19 in the month before delivery
Key Trial Info
Start Date :
June 21 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 22 2025
Estimated Enrollment :
322 Patients enrolled
Trial Details
Trial ID
NCT05197387
Start Date
June 21 2022
End Date
June 22 2025
Last Update
October 16 2024
Active Locations (11)
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1
CHU Angers
Angers, France
2
Polyclinique KERAUDREN
Brest, France, 29200
3
CHU de Brest
Brest, France, 29609
4
CHU de Caen
Caen, France, 14000