Status:
UNKNOWN
Electrical Brain Stimulation for Cognitive Impairment in Schizophrenia: a tDCS-fMRI Study
Lead Sponsor:
The National Brain Mapping Laboratory (NBML)
Collaborating Sponsors:
University of British Columbia
Ruhr University of Bochum
Conditions:
Schizophrenia
Cognitive Impairment
Eligibility:
All Genders
18-50 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to investigate the mechanism of action of transcranial electrical brain stimulation over the dorsolateral prefrontal cortex for cognitive impairment in schizophrenia. To d...
Detailed Description
Thirty schizophrenic patients will be recruited after meeting the inclusion criteria and will be randomly assigned to active and sham stimulation groups. A single session of concurrent prefrontal tDCS...
Eligibility Criteria
Inclusion
- men or women (18-50 yrs old) with a DSM 5 SCZ diagnosis,
- If female, negative urine pregnancy test
- significant cognitive impairment (1 SD below the norm on the working memory/executive functioning task performance)
- feasibility for tDCS interventions according to safety guidelines
- stable medication regime especially the classical neuroleptics and all CNS-activating medications, if taken, 4-6 weeks before the experiment
- fluency in the native language
- right-handed
- ability to provide informed consent.
Exclusion
- pregnancy
- alcohol or substance dependence
- history of seizure
- history of neurological disorder
- history of head injury
- Presence of ferromagnetic objects in the body that are contraindicated for MRI of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments) or fear of enclosed spaces). Eligibility will be determined by the "MRI Safety Screening Questionnaire" and verified, if necessary, by a radiology consultant.
Key Trial Info
Start Date :
February 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05200962
Start Date
February 1 2022
End Date
August 1 2024
Last Update
November 13 2023
Active Locations (1)
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1
The National Brain Mapping Laboratory (NBML)
Tehran, Iran