Status:
RECRUITING
Camrelizumab Combined With Neoadjuvant Chemotherapy After Stent Placement for Left-Sided Obstructive Colonic Cancer
Lead Sponsor:
Beijing Chao Yang Hospital
Conditions:
Colorectal Cancer
Neoadjuvant Chemotherapy
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Patients with obstruction are associated with worse oncologic outcomes compared with those having nonobstructive tumors. Conventionally, patients with malignant large bowel obstruction receive emergen...
Detailed Description
We hypothesis that, regardless of the MSI state, immunotherapy combined with immediate chemotherapy after stenting may improve overall survival by eradicating micrometastasis. Moreover, immunotherapy ...
Eligibility Criteria
Inclusion
- Radiologically proven colonic obstruction of the left colon/upper rectum presumed secondary to a carcinoma
- Able to give written, informed consent
- Primary tumor was resectable
- ECOG score 0 or 1
- Haemoglobin greater than 100 g/L after transfusion before chemotherapy,
- White blood cells greater than 3.0×10# /L
- Platelets greater than 100×10# / L;
- Glomerular filtration rate greater than 50 mL per minute as calculated by the Wright or Cockroft formula
- Bilirubin less than 1.5×Upper Limit of Normal(ULN)
- ALT and AST less than 2.5×ULN
Exclusion
- Distal rectal cancers(equal or less than 10cm from the anal verge)
- Patients with signs of peritonitis and/or bowel perforation
- Patients who did not give informed consent
- Patients who were considered unfit for operative treatment or refuse surgery.
- Patients with suspected or proven metastatic adenocarcinoma;
- Patients with unresectable colorectal cancer, or planning for palliative treatment.
Key Trial Info
Start Date :
December 12 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05202314
Start Date
December 12 2021
End Date
December 30 2026
Last Update
February 21 2023
Active Locations (1)
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1
Beijing Chaoyang Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100020