Status:
RECRUITING
Improving Early Reperfusion With Adjuvant Dornase Alfa in Large Vessel Ischemic Stroke (EXTEND-IA DNase)
Lead Sponsor:
University of Melbourne
Conditions:
Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Patients presenting to the emergency department with acute ischemic stroke, who are are eligible for standard intravenous thrombolytic therapy within 4.5 hours of stroke onset will be assessed for maj...
Eligibility Criteria
Inclusion
- Patients presenting with acute ischemic stroke eligible, using standard criteria, to receive IV thrombolytics within 4.5 hours of stroke onset
- Patient's age is ≥18 years
- Intention to perform endovascular thrombectomy Imaging inclusion criteria
- Arterial occlusion on CTA or MRA of the ICA, M1, M2 or basilar artery
Exclusion
- Intracranial hemorrhage (ICH) identified by CT or MRI
- Rapidly improving symptoms at the discretion of the investigator
- Pre-stroke mRS score of ≥ 4 (indicating previous disability)
- Hypodensity in \>1/3 MCA territory or equivalent proportion of basilar artery territory on non-contrast CT
- Contraindication to imaging with contrast agents
- Any terminal illness such that patient would not be expected to survive more than 1 year
- Any condition that, in the judgment of the investigator could impose hazards to the patient if study therapy is initiated or affect the participation of the patient in the study.
- Pregnant or lactating women
Key Trial Info
Start Date :
February 18 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT05203224
Start Date
February 18 2022
End Date
December 31 2025
Last Update
June 28 2024
Active Locations (3)
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1
Princess Alexandra Hospital
Brisbane, Queensland, Australia, 4102
2
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
3
Royal Melbourne Hospital
Melbourne, Victoria, Australia, 3050