Status:
COMPLETED
Respiratory Mechanics Assessment During Assisted Mechanical Ventilation
Lead Sponsor:
University of Milano Bicocca
Conditions:
Acute Hypoxemic Respiratory Failure
Eligibility:
All Genders
18+ years
Brief Summary
To verify the association between respiratory system mechanical properties (ΔP, ΔPL,dyn, Pmus, Pplat and CRS and CL,dyn) assessed during assisted modes of ventilation (as average over the first three ...
Eligibility Criteria
Inclusion
- Acute Hypoxaemic Respiratory Failure (defined as respiratory failure requiring invasive mechanical ventilation with a PaO2/FiO2\< 300 mmHg) during the course of ICU stay (including ARDS).
- Invasive mechanical ventilation in one of these modes: Pressure A/C, PRVC, SIMV PC, PSV, NAVA, PAV+, BiPAP
- Presence of spontaneous breathing activity (ventilator triggering), since 6 hours and no longer than 48 hours
- Patient for full active management at this point.
Exclusion
- Age \<18 years old
- Pregnancy
- Active air leaks
- Moribund state
- High ICP
- Patient has passed a spontaneous breathing trial (if performed for clinical indication)
- Known COPD with history of home oxygen therapy and/or non invasive ventilation and/or GOLD III-IV. Non invasive ventilation for sleep apnea is NOT an exclusion criteria.
Key Trial Info
Start Date :
September 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 3 2023
Estimated Enrollment :
298 Patients enrolled
Trial Details
Trial ID
NCT05203536
Start Date
September 1 2021
End Date
June 3 2023
Last Update
May 30 2025
Active Locations (8)
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1
Toronto General Hospital
Toronto, Toronto, Canada, M5G 2C4
2
University Medical Centre Schleswig-Holstein
Kiel, Kiel, Germany, 24105
3
University Hospital Galway
Galway, Galway, Ireland, YR71
4
Ospedale Sant'Anna
Ferrara, Ferrara, Italy, 44124