Status:
COMPLETED
Lactate for Energy and Neurocognition
Lead Sponsor:
University of Kansas Medical Center
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Healthy Aging
Alzheimer Disease
Eligibility:
All Genders
60-95 years
Brief Summary
Improved cardiorespiratory fitness following an aerobic exercise program elicits cognitive benefit in elderly subjects and memory improvement in Alzheimer's disease (AD). The physiological mechanism m...
Detailed Description
Alzheimer's disease (AD) is the most common neurodegenerative disease, affecting over 5 million Americans, with this number expected to balloon to nearly 14 million by 2050. Annual health care costs a...
Eligibility Criteria
Inclusion
- Age 60 and older
- Stable medication doses (\>1month)
- Post-menopausal
- Diagnosis of either Nondemented (CDR 0) or Probable AD (CDR 0.5 or 1 only)
Exclusion
- Inability to provide consent
- Diagnosis of insulin-dependent (Type 1) Diabetes Mellitus
- Anti-platelet medication (Plavix), Warfarin, and other anticoagulants (Eliquis, Pradaxa, and Xarelto)
- Recent ischemic heart disease (\<2 years)
- Diagnosis of a clinically significant chronic disease including CVD, other metabolic diseases (e.g., thyroid), cancer, HIV, or acquired immunodeficiency syndrome
- Any Neurological disorders that have the potential to impair cognition or brain metabolism (e.g., Parkinson's disease, stroke defined as a clinical episode with neuroimaging evidence in an appropriate area to explain the symptoms).
- Clinically significant depressive symptoms that may impair cognition, abnormalities in B12, RPR, or thyroid function that may impair cognition, use of psychoactive and investigational medications, and significant visual or auditory impairment
Key Trial Info
Start Date :
April 12 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 29 2024
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT05207397
Start Date
April 12 2023
End Date
March 29 2024
Last Update
May 14 2025
Active Locations (1)
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1
Univeristy of Kansas Medical Center
Kansas City, Kansas, United States, 66160