Status:
UNKNOWN
Study of Motor Inhibition in Parkinson's Disease and Focal Hand Dystonia
Lead Sponsor:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Conditions:
Parkinson Disease
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The current research protocol aims at studying preparatory inhibition in two populations of patients suffering from movement disorders. First, in PART 1, we will work with Parkinson's disease (PD) pat...
Detailed Description
Any movement requires some planning, relying substantially on neural cells in the frontal cortex connected with spinal circuits, which themselves help regulating muscle activity. These corticospinal p...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Diagnosis of idiopathic PD (according to the United Kingdom PD Society Brain Bank Clinical Diagnostic Criteria) (for PD participants)
- Good response to levodopa (improvement on the UPDRS-III scale) (for PD participants)
- Hoehn and Yahr stage: \< or = 3 (for PD participants)
- Absence of severe tremor (for PD participants)
- Absence of dyskinesia (for PD participants)
- Between 18 and 85 years old (for all participants)
- Normal or corrected-to-normal vision (for all participants)
- Exclusion Criteria (for all participants):
- Severe cognitive impairment (Score of \<21/30 with the Montreal Cognitive Assessment (MoCA))
- MRI-incompatible metal device in the body
- History of major psychiatric or neurological disorder (other than PD for the patient group)
- Personal or family history of epilepsy
- History of substance use disorder (except nicotine)
- Untreated or unstable medical conditions that could interfere with cognitive functioning
- Undergoing any drug treatment that can significantly alter task performance or neural activity
Exclusion
Key Trial Info
Start Date :
July 31 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 23 2023
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT05209516
Start Date
July 31 2018
End Date
April 23 2023
Last Update
January 26 2022
Active Locations (1)
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1
Cliniques universitaires Saint-Luc
Brussels, Belgium, 1200