Status:
COMPLETED
Effects of Polynucleotides and Hyaluronic Acid Based Subgingival Periodontal Pockets Re-instrumentation
Lead Sponsor:
University of Roma La Sapienza
Conditions:
Periodontal Pocket
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this randomized controlled clinical trial (RCT) was to investigate the clinical and biochemical efficacy of a gel containing PDRN and HA used in association with subgingival re-instrume...
Detailed Description
The aim of the present study was to investigate the clinical and biochemical efficacy of a gel containing polynucleotides (PDRN) and hyaluronic acid (HA) used in association with subgingival re-instru...
Eligibility Criteria
Inclusion
- males and females with ≥ 18 years
- stage 3 generalized periodontitis
- 3-6 months after step 1 and 2 of periodontal treatment, at least two non-adjacent teeth showing one residual pocket with probing depth (PD) ≥5, without mobility and without furcation involvement.
Exclusion
- full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) \>20%
- inadequate restorative therapy or malocclusion
- uncontrolled systemic disease
- immunosuppressive therapy or therapy with corticosteroid or with bisphosphonates
- inflammatory and autoimmune diseases of the oral cavity
- history of malignancy, radiation therapy or chemotherapy for malignancy in the last 5 years
- insulin-dependent diabetes;
- smoking (\> 10 cigarettes per day)
- drug and alcohol abuse
- pregnant or lactating.
Key Trial Info
Start Date :
February 19 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 13 2019
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05210686
Start Date
February 19 2018
End Date
December 13 2019
Last Update
May 17 2022
Active Locations (1)
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1
Department of Oral and Maxillofacial Sciences. Section of Periodontics.Sapienza, University of Rome
Rome, Italy, 00161