Status:
COMPLETED
HFNC and Hypoxia/Desaturation During Radiofrequency Ablation Under Moderate Sedation: A Randomized Clinical Trial
Lead Sponsor:
Zhejiang Cancer Hospital
Conditions:
Propofol
Hypoxia
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Background: Propofol based sedated anesthesia was widely used in percutaneous radiofrequency ablation and hypoxia/desaturation is one of the most frequent adverse events during this procedure. No effe...
Detailed Description
After received the approvement of ethics committee of the Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital, approval number IRB-2022-262). The study was regis...
Eligibility Criteria
Inclusion
- 18\< age \< 75 years;
- ASA physical state I and II; .Undergoing percutaneous radiofrequency ablation.
Exclusion
- Age \< 18 years or older than 75 years;
- America Society of Anesthesiologists (ASA) class \>III;
- Allergic to anesthetic solutions;
- Tendency for nose bleeding or coagulation disorders;
- Local infection (eg. mouth, nose, or throat infection);
- Heart disease like congestive heart failure, severe aortic stenosis or mitral stenosis, cardiac surgery involving thoracotomy (eg, coronary artery bypass graft or valve replacement surgery) in the last 6 months; acute myocardial infarction in the last 6 months; acute arrhythmia (including tachycardia and bradycardia) with hemodynamic instability;
- Diagnosed chronic obstructive pulmonary disease (COPD) or other current acute or chronic lung diseases requiring supplemental chronic or intermittent oxygen therapy;
- Increased intracranial pressure;
- Fever, defined as core body temperature \>37.5 C;
- Severe anemia (30g/L\< hemoglobin \<6g/L);
- Emergency surgery;
- Patients refuse to participate;
Key Trial Info
Start Date :
January 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 17 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05212064
Start Date
January 1 2022
End Date
August 17 2023
Last Update
February 12 2024
Active Locations (1)
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1
Zhejiang Cancer hospital
Hangzhou, Zhejiang, China, 310000