Status:
ENROLLING_BY_INVITATION
PET Imaging of Cancer Patients Using 68Ga-DOTA-Siglec-9
Lead Sponsor:
Turku University Hospital
Conditions:
Acute Myeloid Leukemia
Melanoma
Eligibility:
All Genders
18-100 years
Brief Summary
This is a scientific study to determine expression of vascular adhesion protein 1 (VAP-1) in cancer patients by 68Ga-DOTA-Siglec-9 positron emission tomography/computed tomography (PET/CT) before and ...
Detailed Description
The purpose of this study is to evaluate expression of vascular adhesion protein 1 (VAP-1) in bone marrow and cancerous lesions before and after therapy using 68Ga-DOTA-Siglec-9 positron emission tomo...
Eligibility Criteria
Inclusion
- Diagnosis of acute myeloid leukemia (AML) and fit for allogeneic hematopoietic stem cell transplantation (alloHSCT), as assessed in the standard operating procedures.
- Diagnosis of metastatic melanoma and fit for immune checkpoint inhibitors or BRAF- and MEK inhibitors.
- Diagnosis of metastatic non-small cell lung cancer (NSCLC) (stage IV) and fit for immune checkpoint inhibitors and/or chemotherapy.
- Able and willing to give written informed consent and to comply with the study protocol.
Exclusion
- Unsuitable for alloHSCT (AML), checkpoint inhibitors or BRAF- and MEK inhibitors (melanoma or checkpoint inhibitors and/or chemotherapy (NSCLC) according to the standard operating procedures.
- Unable or unwilling to comply with the study protocol for any reason.
- Evidence of significant uncontrolled concomitant diseases such as neurological, renal, hepatic, endocrine, or gastrointestinal disorders which, in the opinion of the Investigator, would preclude patient participation
Key Trial Info
Start Date :
September 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05212103
Start Date
September 1 2023
End Date
December 31 2026
Last Update
December 4 2024
Active Locations (1)
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1
Turku University Hospital, Turku PET Centre
Turku, Finland