Status:
ENROLLING_BY_INVITATION
Long-term Pain Modulation by Intravenous Esketamine in CRPS
Lead Sponsor:
Erasmus Medical Center
Conditions:
Complex Regional Pain Syndromes
CRPS (Complex Regional Pain Syndromes)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Intravenous administration of esketamine is an effective recognized therapeutic option in refractory pain in CRPS, which sometimes in at least a part of the patients has a prolonged therapeutic effect...
Detailed Description
Rationale: Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition of one or more limbs. Its diagnosis is based on (combinations of) underlying pathophysiological mechanisms. Ac...
Eligibility Criteria
Inclusion
- Meeting the new International Association for the Study of Pain (IASP) diagnostic criteria for CRPS ("the Budapest Criteria) (Harden et al., 2010) or having met the new IASP diagnostic criteria of CRPS ("CRPS with Remission of Some features") (Goebel et al., 2021).
- Willing and capable to participate in the study.
- CRPS in one upper extremity and/or CRPS in one lower extremity
- Treatment in an elective setting.
- Adequate comprehension of the Dutch language
- Age ≥ 18 years
Exclusion
- Severe liver disease
- Psychiatric (schizophrenia, psychosis, delirium, manic depression)
- Active substance abuse
- Intoxication with alcohol or other substances
- Poorly controlled hypertension
- Unstable angina
- High-risk coronary vascular disease
- Heart failure
- Elevated intracranial pressure
- Elevated intraocular pressure
- Thyrotoxicosis
- Pregnancy
- Combination with derivates of xanthines (theophylline) or ergometrine
Key Trial Info
Start Date :
April 19 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05212571
Start Date
April 19 2022
End Date
October 1 2027
Last Update
September 11 2023
Active Locations (1)
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1
Erasmus MC
Rotterdam, South Holland, Netherlands, 3000 CA