Status:
COMPLETED
Using Repetitive Transcranial Magnetic Stimulation to Study the Role of Frontostriatal Circuit in Major Depressive Disorder
Lead Sponsor:
National Cheng-Kung University Hospital
Collaborating Sponsors:
Ministry of Science and Technology, Taiwan
Conditions:
Depressive Disorder, Major
Eligibility:
All Genders
20-70 years
Phase:
NA
Brief Summary
Major depressive disorder (MDD) is a common, severe, and often life-threatening illness that involves the body, mood, and thoughts. The natural course of MDD tends to worsen without treatment, while p...
Detailed Description
BACKGROUNDＡND SIGNIFICANCE: 1. The scale of the global impact of MDD is substantial, with mental illness constituting an estimated 7.4% of the world's measurable burden of disease. With a period of s...
Eligibility Criteria
Inclusion
- meet the DSM-5 diagnostic criteria and their current episode show a 17-item Hamilton Rating Scale for Depression (HRSD-17) score of at least 18
- show no clinical response to an adequate dose of an antidepressant
- could not tolerate at least two antidepressants in the current episode will be enrolled consecutively by trained psychiatrists
- Patients should receive a stable antidepressant regimen for at least 4 weeks before screening and continue during treatment
Exclusion
- had DSM-5 diagnosis for substance abuse within the past three months
- had taken monoamine oxidase inhibitors
- had an organic mental disorder, mental retardation, dementia, or other diagnosed neurological illness
- had a surgical condition or a major physical illness
- underwent course of electroconvulsive therapy (ECT) within the last three months
- the presence of a cardiac pacemaker, intracranial implant, or metal in the cranium
- taking any anticonvulsant or if more than three adequate antidepressant trials had failed (determined by antidepressant treatment history form).
Key Trial Info
Start Date :
August 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 31 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05212636
Start Date
August 1 2020
End Date
October 31 2021
Last Update
January 28 2022
Active Locations (1)
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1
National Cheng-Kung University
Tainan, Taiwan, 704