Status:
ENROLLING_BY_INVITATION
Effectiveness of iPRF Injections in Temporomandibular Joints Degeneration Management
Lead Sponsor:
Wroclaw Medical University
Conditions:
Temporomandibular Disorder
Temporomandibular Joint Disorders
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
PHASE3
Brief Summary
The aim of the study is to evaluate the effectiveness of intra-articular platelet-rich fibrin (iPRF) injections in the management of moderate and mild cases of degeneration of the temporomandibular jo...
Detailed Description
Background: The term temporomandibular disorders is used to describe a wide spectrum of functional modifications and pathological conditions involving the temporomandibular joints, masticatory muscles...
Eligibility Criteria
Inclusion
- age between 18 and 80 years old
- mild to moderate degenerative temporomandibular joint disease based on DC/TMD protocol and MRI/CT
- agreement to take part in the study
Exclusion
- severe hematologic and/or neurological disorder
- rheumatoid arthritis
- septic arthritis
- polymyalgia rheumatica
- gout
- Paget's disease
- osteonecrosis
- connective tissue disease
- malignant disease
- vasculitis
- any previous temporomandibular joint (TMJ) invasive treatment
- any current temporomandibular joint (TMJ) conservative or invasive treatment
- patients who had used oral, parenteral or intra-articular corticosteroids in the 3 months prior to the first injection
- previous or current radiotherapy of head and neck
- pregnancy or lactation
- presence of severe mental disorders
- drug and/or alcohol addiction
- presence of local contraindications for injection therapy
- patients with needle phobia
- presence of hypersensitivity to substances to be used in the study
Key Trial Info
Start Date :
January 24 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT05214924
Start Date
January 24 2022
End Date
December 31 2025
Last Update
July 16 2025
Active Locations (1)
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1
Wroclaw Medical University
Wroclaw, Poland