Status:
RECRUITING
Ex Vivo Characterization and Targeting of the Latent HIV Infected Reservoir to Cure HIV
Lead Sponsor:
Erasmus Medical Center
Conditions:
HIV Infections
HIV-1-infection
Eligibility:
All Genders
18+ years
Brief Summary
Combination antiretroviral therapy (cART) blocks intracellular human immunodeficiency virus (HIV) replication in CD4+ T-lymphocytes, but fails to eliminate latent HIV infected CD4+ T-lymphocytes. Abou...
Detailed Description
This is a prospective cross-sectional cohort study used for ex vivo studies using material from HIV infected individuals. Peripheral blood mononuclear cells (PBMC's) and whole blood are obtained throu...
Eligibility Criteria
Inclusion
- Age 18 years or older.
- Confirmed HIV-1 or HIV-2 infection.
Exclusion
- Inability to place 2.5 cm venous catheter or perform phlebotomy
- Major comorbidities:
- A. Severe symptomatic anemia B. Recent symptomatic cardiovascular event (unstable angina pectoris, decompensated heart failure, myocardial infarction).
- The inability to participate due to any other relevant medical, social, environmental, psychological, factors or according to the HIV treating physician's judgement
Key Trial Info
Start Date :
January 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2030
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05215704
Start Date
January 1 2012
End Date
December 31 2030
Last Update
February 14 2024
Active Locations (1)
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1
Erasmus Medical Centre
Rotterdam, Netherlands