Status:
UNKNOWN
Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis
Lead Sponsor:
Mahidol University
Collaborating Sponsors:
Ministry of Health, Thailand
Conditions:
Tuberculosis, Pulmonary
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
This study was a randomized controlled trial studying about acid-fast bacillus sputum conversion ratio from positive to negative of pulmonary tuberculosis patients between metformin with pulmonary tub...
Detailed Description
1. Pulmonary tuberculosis Patients with presence of at least one acid-fast bacillus in the sputum will be examined by an internist. 2. Collect the necessary basic information of patients who agree to ...
Eligibility Criteria
Inclusion
- Age more than 18 years old
- Be diagnosed pulmonary tuberculosis compatible with clinical and chest x ray by an internist
- Presence of at least one acid -fast bacillus in the sputum
- Recieve pulmonary tuberculosis standard treatment compose of isoniazid, rifampicin, pyrazinamide and ethambutol
- BMI more than 18.5 kg/m2
- Reserach participants were diagnosed diabetes or non diabetes.
- Research participants or representatives are welcome to join the project by signing.
Exclusion
- Pregnancy
- Organ transplants
- eGFR less than 45 ml/min/1.73 m2
- AST, ALT or total bilirubin more than three times
- Researh participants have received metformin at least 2 weeks before joining the project.
- Immunocompromised host such as patient receive systemic immunosuppressive drugs or systemic chemotherapy.
- Research participant or his representative refuses or requests to withdraw,
Key Trial Info
Start Date :
January 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2023
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT05215990
Start Date
January 15 2022
End Date
March 31 2023
Last Update
February 14 2022
Active Locations (1)
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1
Angsana Phuphuakrat
Ratchathewi, ฺBangkok, Thailand, 10400