Status:
COMPLETED
Oleuropein and Muscle Energy Metabolism
Lead Sponsor:
Société des Produits Nestlé (SPN)
Collaborating Sponsors:
Maastricht University Medical Center
Conditions:
Muscular Fatigue
Eligibility:
MALE
50-70 years
Phase:
NA
Brief Summary
Preclinical studies performed at Nestlé Research (NR) identified oleuropein as a novel activator of mitochondrial calcium import. This potentiated mitochondrial calcium uptake resulted in decreased ph...
Eligibility Criteria
Inclusion
- Male
- 50 to 70 years old
- BMI 18.5-29.9 kg/m2
- Healthy as per medical history and investigator's/ physician's judgement
- Having given informed consent
Exclusion
- Allergy/intolerance to the study product
- \>5% body mass change in the previous 3 months
- HbA1c ≥ 6.5%
- Blood pressure \>140/90 mmHg
- Participating in a structured (progressive) exercise program
- Smoking
- Diagnosed acute or chronic medical conditions that, in the opinion of the investigator, could impact study outcomes
- Diagnosed musculoskeletal disorders
- Chronic use of gastric acid suppressing medication
- Unauthorized concomitant medications such as calcium antagonists (e.g. valproate), oral corticosteroids, anything that will prevent subjects from safely completing the study according to the investigator or medications / drugs known interfering with the expected mechanism of action of IP or to affect the outcome parameters
- Alcohol (intake higher than 3 servings per day. One serving is 0.4 dl of alcohol, 1 dl of wine, or 3 dl of beer) or drug abuse
- Overly imbalanced or restrictive diet (e.g. hyperproteic, vegan, ketogenic, etc.)
- Subjects not willing and/or not able to comply with scheduled visits and the requirements of the study protocol
- Any implants that would be a contra-indication for performing an MRI scan.
- Participation in another study at the same time
- Blood donation in the past 2 months
Key Trial Info
Start Date :
November 4 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 10 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05217433
Start Date
November 4 2021
End Date
March 10 2023
Last Update
March 17 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Maastricht University Medical Centre +
Maastricht, Netherlands