Status:
UNKNOWN
Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia
Lead Sponsor:
University of British Columbia
Collaborating Sponsors:
Genome British Columbia
Vancouver Coastal Health Research Institute
Conditions:
Familial Hypercholesterolemia
Familial Hypercholesterolemia Due to Genetic Defect of Apolipoprotein B
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
ACCURATE will test the hypothesis that opportunistic genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coronary syndrome will increase the diagnosis...
Detailed Description
Familial hypercholesterolemia (FH) is an inherited condition characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels and premature atherosclerotic cardiovascular disease (ASCVD). ...
Eligibility Criteria
Inclusion
- Age \<60 years
- AND
- Admitted to an acute cardiac unit with either:
- A ST elevation myocardial infarction (STEMI), or
- A non-ST elevation myocardial infarction (NSTEMI)
- AND
- Maximum lipid level at the time of admission or during the prior 1 year of
- LDL level ≥4 mmol/L (154 mg/dL) if not on a statin, or
- LDL-C level ≥2.5 mmol/L (96 mg/dL) if on a statin prior to presentation, or
- Non-HDL-C ≥4.6 mmol/L (177 mg/dL) if LDL-C not available
Exclusion
Key Trial Info
Start Date :
January 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2025
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT05218005
Start Date
January 1 2022
End Date
April 1 2025
Last Update
May 16 2023
Active Locations (2)
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1
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9
2
St.Pauls Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6