Status:
COMPLETED
Evaluating ATSBs for Malaria Reduction in Kenya
Lead Sponsor:
Liverpool School of Tropical Medicine
Collaborating Sponsors:
Kenya Medical Research Institute
Centers for Disease Control and Prevention
Conditions:
Malaria
Eligibility:
All Genders
1+ years
Phase:
NA
Brief Summary
The effectiveness of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) in western Kenya are threatened by insecticide resistance and vector behaviour changes toward early eveni...
Detailed Description
The current malaria vector control tools, long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are critically important and have saved many lives. However, their effectiveness in ...
Eligibility Criteria
Inclusion
- Eligibility criteria for clusters: Inclusion criteria
- A grouping of contiguous rural villages in Alego-Usonga and Rarieda sub-counties of Siaya County
- A minimum of 200 households
- Eligibility criteria for clusters: Exclusion criteria
- Hard to reach in the rainy season
- Refusal to participate by village elders
- Eligibility criteria for participants in the cohort study: Inclusion criteria
- A resident of a household within the core area of a study cluster, defined as living in the household in the recent four months and planning to live in the same household for the next 6.5 months
- Aged ≥ 1 year and \< 15 years at the time of enrollment
- Written informed consent and/or assent
- Eligibility criteria for participants in the cohort study: Exclusion criteria
- A confirmed or suspected pregnancy. Pregnant women are excluded because they are eligible for intermittent preventive treatment of malaria in pregnancy (IPTp).
- Taking daily cotrimoxazole prophylaxis (because this has antimalarial effects)
- Known sickle cell disease (because they received antimalarial prophylaxis)
- Contraindication to artemether-lumefantrine, the medication used for parasite clearance
- Eligibility criteria for households for ATSB deployment: Inclusion criteria
- -Households located within one of the 40 clusters (core or buffer area) randomly allocated to the trial intervention arm with a least one permanent resident
- Eligibility criteria for households for ATSB deployment: Exclusion criteria
- Refusal of consent by the head-of-household to deploy ATSB on the outer walls (intervention villages only)
- Vacated compounds
- Eligibility criteria for households for entomological monitoring: Inclusion criteria
- Household located within the core area of the cluster
- Head of household or his/her representative is at least 18 years of age
- Written informed consent for the collection of entomological data by the head of household or representative
- Eligibility criteria for households for entomological monitoring: Exclusion criteria --No residents sleeping in the household during the planned night of monitoring
- Eligibility criteria for human landing catches: Inclusion criteria
- Men aged 18 to 49 years
- Willingness and ability to work late at night for up to 7 hours at a time
- Willingness to take and tolerate a treatment regimen of the appropriate Kenya Ministry of Health (MoH) recommended antimalarial and chemoprophylaxis with 250 mg of mefloquine weekly to prevent malaria starting two weeks before the start of and until four weeks after completing HLCs
- Written informed consent
- Eligibility criteria for human landing catches: Exclusion criteria
- Refusal/inability to work late at night for up to 7 hours at a time
- Unwillingness to take or intolerance/allergy to appropriate MoH treatment regimen or chemoprophylaxis
- Eligibility criteria for participants in rapid ethnographic methods evaluation (community members): Inclusion criteria
- A resident of a household within an intervention area defined as an ATSB area during the main trial or an ASB area during any preliminary studies
- Resides in a household at the time of ASB/ATSB deployment, where the ASB/ATSB was installed for at least one month.
- 18 years of age or older if participating in focus group discussions; 15 years of age or older if participating in in-depth interviews
- Eligibility criteria for participants in rapid ethnographic methods evaluation (community members): Exclusion criteria
- -Unable to provide consent
- Eligibility criteria for participants in rapid ethnographic methods evaluation (ATSB monitoring assistants): Inclusion criteria
- Inclusion criteria ethnographic evaluation (ATSB monitoring assistants)
- Serving as an ATSB monitoring assistant with experience installing ATSBs and monitoring the deployment Eighteen years of age or older
- Eligibility criteria for participants in rapid ethnographic methods evaluation (ATSB monitoring assistants): Exclusion criteria
- Less than one month experience (i.e. is new to the job)
- Unable to provide consent
Exclusion
Key Trial Info
Start Date :
March 7 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 24 2024
Estimated Enrollment :
2962 Patients enrolled
Trial Details
Trial ID
NCT05219565
Start Date
March 7 2022
End Date
April 24 2024
Last Update
June 10 2024
Active Locations (9)
Enter a location and click search to find clinical trials sorted by distance.
1
Naya Health Centre
Siaya, Siaya County, Kenya, 20200
2
Benga Dispensary
Siaya, Siaya County, Kenya
3
Boro Dispensary
Siaya, Siaya County, Kenya
4
Manyuanda Health Centre
Siaya, Siaya County, Kenya