Status:

RECRUITING

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Lead Sponsor:

University of Missouri-Columbia

Conditions:

Obesity

Vasodilation

Eligibility:

All Genders

18-45 years

Phase:

EARLY_PHASE1

Brief Summary

The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.

Detailed Description

Patients with sleep apnea are at increased risk of developing cardiovascular disease - with women at potentially greater risk than men. Contributing mechanisms are not well understood, but may be rela...

Eligibility Criteria

Inclusion

  • BMI \>18 kg/m2

Exclusion

  • Pregnancy, breastfeeding
  • Diagnosed sleep apnea or AHI \>10 events/hr
  • Current smoking/Nicotine use
  • Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
  • Nerve/neurologic disease
  • Cardiovascular, hepatic, renal, respiratory disease
  • Blood pressure ≥140/90 mmHg
  • Diabetes, Polycystic ovarian syndrome
  • Communication barriers
  • Prescription medications, Sensitivity to lidocaine

Key Trial Info

Start Date :

March 14 2023

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

June 30 2026

Estimated Enrollment :

72 Patients enrolled

Trial Details

Trial ID

NCT05219799

Start Date

March 14 2023

End Date

June 30 2026

Last Update

May 29 2025

Active Locations (1)

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1

University of Missouri

Columbia, Missouri, United States, 65211