Status:
COMPLETED
Omega-3 Fatty Acid Supplementation and Fractional Iron Absorption in Obese South African Women
Lead Sponsor:
Swiss Federal Institute of Technology
Collaborating Sponsors:
North-West University, South Africa
Conditions:
Obesity
Eligibility:
FEMALE
18-35 years
Phase:
NA
Brief Summary
In South Africa the prevalence of obesity in women of reproductive age is high; these women also have a high risk for iron deficiency (ID). Obesity is associated with low-grade systemic inflammation, ...
Detailed Description
Iron deficiency (ID) and iron-deficiency anaemia (IDA) remain a major public health problem in low- and middle-income countries (LMICs). Women of reproductive age are at high risk of developing ID due...
Eligibility Criteria
Inclusion
- Self-classified women from African descent and of reproductive age (18 - 35 years)
- BMI ≥ 28kg/m2 (indicating obesity)
- Midly- or non-anaemic (Hb ≥11 g/dl)
- Low n-3 LCPUFA status (RBC omega-3 index \< 6%)
- Low grade systemic inflammation (HS-CRP ≥ 2 mg/l but ≤ 20 mg/l)
- Be able to read and understand English
Exclusion
- Treated chronic disease or gastrointestinal disorders
- Regular use of medication (except oral contraceptives, others after approval by the investigator) and women receiving treatment for high blood pressure
- Current consumption of iron or n-3 LCPUFA or ascorbic acid-containing supplements other than the supplements provided (Participants will be asked to discontinue use three weeks prior to enrolment)
- Subject on a weight loss diet or planning to start a weight loss diet during the duration of the study
- Pregnancy or lactation
- Subjects who cannot be expected to comply with the study protocol
- Subjects who are smoking
- Difficulty drawing blood due to poor quality veins
- Individuals that have a fear of needles or suffer from vaso-vagal episodes when exposed to blood
- Subjects with fish allergies
- Participants who plan to start or stop the use of contraceptives in the following 4 months.
Key Trial Info
Start Date :
March 7 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2023
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT05220735
Start Date
March 7 2022
End Date
September 30 2023
Last Update
November 22 2023
Active Locations (1)
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1
Centre of Excellence for Nutrition, North-West University
Potchefstroom, South Africa