Status:
ACTIVE_NOT_RECRUITING
Accelerated Stress CMR in Coronary Artery Disease
Lead Sponsor:
University of Leicester
Collaborating Sponsors:
University of Glasgow
Imperial College Healthcare NHS Trust
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Brief Summary
This study will evaluate the diagnostic performance of an accelerated stress CMR protocol, comparing it with that of standard CMR assessment.
Detailed Description
This is a prospective, single-centre diagnostic accuracy study comparing the diagnostic performance of (1) accelerated and (2) standard adenosine stress CMR scans in 167 patients with suspected corona...
Eligibility Criteria
Inclusion
- Patients aged ≥18 years
- Referred for invasive coronary angiography for investigation of chest pain
- Willing and able to give informed consent
- Willing and able (in the Investigators opinion) to comply with all study requirements.
- Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study.
- Able to understand written English
Exclusion
- Recent acute coronary syndrome (\< 6 months)
- Severe claustrophobia
- Absolute contraindications to CMR - those with MR conditional or safe devices will be included
- Second-/third-degree atrioventricular block
- Severe chronic obstructive pulmonary disease
- Moderate-severe asthma
- Estimated glomerular filtration rate \<30 ml/min/1.73m2
- Women who are pregnant, breast-feeding or of child-bearing potential (premenopausal women)
- Contraindication to iodinated contrast
- Participants who have participated in a research study involving an investigational product in the past 12 weeks
- Patients unable to understand written English
Key Trial Info
Start Date :
July 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 30 2025
Estimated Enrollment :
167 Patients enrolled
Trial Details
Trial ID
NCT05221762
Start Date
July 1 2021
End Date
November 30 2025
Last Update
July 2 2025
Active Locations (1)
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1
Glenfield Hospital
Leicester, Leics, United Kingdom, LE3 9QP