Status:
COMPLETED
Effects of Inorganic Nitrate and Intensity of Exercise on Cardiovascular Health in Post-Menopausal Females
Lead Sponsor:
University of Virginia
Conditions:
Vascular Dilation
Arterial Stiffness
Eligibility:
FEMALE
45-75 years
Phase:
PHASE1
Brief Summary
Post-menopausal females experience elevated cardiovascular disease risk (CVD), compared to premenopausal females and age-matched males. Current exercise guidelines appear inadequate to ameliorate this...
Detailed Description
The purpose of this study is to determine whether acute inorganic nitrate supplementation and exercising at different exercise intensities (high vs moderate) improve vascular health in post-menopausal...
Eligibility Criteria
Inclusion
- Post-menopausal female, defined as having not had a menstrual cycle for at least 1 year
- Greater than age 45 but less than age 75
- Sedentary (does not exercise regularly)
- No major changes in medication in the last 3 months
Exclusion
- Smokers within last 5 years
- Weight unstable (loss/gain of more than 3kg in the past 3 months)
- Any medical condition that prevents the subject from exercising safely
- Hormone replacement therapy (current or within last 3 months)
- Currently or recently on vasoactive medications (i.e., calcium channel blockers, statins, ACE or renin inhibitors, ARBs, nitrates, alpha- or beta-blockers, diuretics, proton pump inhibitors, etc.)
- Hysterectomy or oophorectomy
Key Trial Info
Start Date :
November 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2023
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT05221905
Start Date
November 1 2021
End Date
April 1 2023
Last Update
November 30 2023
Active Locations (1)
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1
Student Health and Wellness Center
Charlottesville, Virginia, United States, 22902