Status:
RECRUITING
Avalanche Phenomenon During Airways Opening in Acute Respiratory Distress Syndrome
Lead Sponsor:
Poitiers University Hospital
Conditions:
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
Acute respiratory distress syndrome accounts for 23% of mechanically ventilated patients and is associated with high mortality rate. Although life-saving, mechanical ventilation may worsen lung injury...
Eligibility Criteria
Inclusion
- Age ≥ 18
- Moderate-to-severe acute respiratory distress syndrome within the first 72 hours after meeting the Berlin definition criteria:
- Within 1 week of a known clinical insult or new or worsening respiratory symptoms;
- Bilateral opacities (not fully explained by effusions, lobar/lung collapse, or nodules);
- Respiratory failure not fully explained by cardiac failure or fluid overload;
- PaO2/FiO2 ≤ 200 mmHg with positive end-expiratory pressure ≥ 5 cmH2O.
- Absence of spontaneous breathing efforts
- Consent to participate to the study from the patient and/or its surrogate
Exclusion
- Pneumothorax
- Broncho-pleural fistula
- Tracheostomy
- Hemodynamic instability
- Severe hypoxemia
- Suspected of proven intracranial hypertension
- Chronic obstructive lung disease
- Pacemaker or defibrillator
- Decision to withhold of withdraw life-sustaining measures
- Under protection
Key Trial Info
Start Date :
March 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05224323
Start Date
March 1 2022
End Date
October 1 2026
Last Update
December 24 2025
Active Locations (1)
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1
CHU Poitiers
Poitiers, France, 86000