Status:
RECRUITING
Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
Mechanical Ventilation Complication
Pulmonary Edema
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.
Detailed Description
Weaning from mechanical ventilation remains a central step in the management of critically-ill patients, since weaning failure and prolonged duration of mechanical ventilation are not only associated ...
Eligibility Criteria
Inclusion
- Invasive mechanical ventilation for more than 48 hours
- Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the following criteria:
- SpO2\> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O
- Cough effectiveness on tracheal aspirations
- Lack of hemodynamic instability and of disorders of consciousness
- Patients at high risk of weaning-induced pulmonary edema (WIPO), defined by one or more of the following criteria:
- Obesity, defined by a body mass index\> 30 kg/m²
- Chronic obstructive pulmonary disease
- Chronic heart disease
Exclusion
- Age \<18 years and pregnant women
- Patients with a decision of not to resuscitate
- Poor echogenicity
- Severe mitral valve disease (leakage and/or stenosis, bioprosthesis)
- Patients with pacemaker
- Tracheostomy
- Chronic neuromuscular or neurodegenerative diseases
Key Trial Info
Start Date :
August 8 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2024
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT05226247
Start Date
August 8 2022
End Date
September 1 2024
Last Update
February 8 2024
Active Locations (3)
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1
CHU de Dijon
Dijon, France, 21079
2
CHU de NICE
Nice, France, 06200
3
Hôpital Cochin
Paris, France, 75014