Status:
UNKNOWN
Live Birth After Letrozole-stimulated Cycles Versus Hormone Replacement Treatment Cycles for the First Frozen Embryo Transfer in Women With PCOS
Lead Sponsor:
Reproductive & Genetic Hospital of CITIC-Xiangya
Conditions:
PCOS
Eligibility:
FEMALE
20-38 years
Phase:
NA
Brief Summary
This is a multicenter randomized controlled trial comparing the efficacy and safety of two endometrial preparation protocols for the first frozen embryo transfer cycle in PCOS with whole embryo freezi...
Eligibility Criteria
Inclusion
- 1\. women diagnosed with PCOS according to modified Rotterdam criteria;
- 2\. Women who are participating in their first cycle of IVF or ICSI.
- 3\. Women whose IVF/ICSI ovarian stimulation protocol was either GnRH antagonist protocol or long agonist protocol.
- 4\. Women with whole embryos freezing.
- 5\. Women aged 20 to 38 years old;
- 6\. Women BMI 18 kg/m2 to 30 kg/m2
- 7\. Women with at least one good-quality embryo suitable for transfer, including day 3 cleavage stage embryo with grade 7CI /8CI and day 5 or day 6 blastocyst with grade 4BB or higher.
Exclusion
- 1\. Women who has a history of recurrent spontaneous abortion.
- 2\. Women with unilateral/bilateral oophorectomy.
- 3\. Women with untreated Hydrosalpinx.
- 4\. Women with a uterine cavity abnormality, such as a uterine congenital malformation, untreated uterine septum (except shallow uterine septum), adenomyosis, submucous myoma, or moderate to severe intrauterine adhesions.
- 5\. Women with uncontrolled diabetes mellitus, thyroid disease and hypertension.
- 6\. Women who are indicated and planned to undergo preimplantation genetic test (PGT).
Key Trial Info
Start Date :
March 16 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
1078 Patients enrolled
Trial Details
Trial ID
NCT05227391
Start Date
March 16 2022
End Date
December 31 2024
Last Update
June 22 2023
Active Locations (1)
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1
Reproductive & Genetic Hospital of CITIC-Xiangya
Changsha, Hunan, China, 410000