Status:
ACTIVE_NOT_RECRUITING
Enhancing Brain Health by TDCS in Persons with Overweight and Obesity
Lead Sponsor:
University Hospital Tuebingen
Conditions:
Insulin Resistance
Obesity
Eligibility:
All Genders
20-65 years
Phase:
NA
Brief Summary
Disturbances in the hypothalamus communication pathways with other regions in the brain and the periphery may represent a potential link between metabolic and cognitive health. The current project eva...
Detailed Description
The overarching aim of the study is to investigate the possibility to enhance neuroplasticity of the hypothalamus network to improve metabolism and dopamine-dependent cognitive functions. Specific ob...
Eligibility Criteria
Inclusion
- Written consent to participate in the study
- Written consent to be informed about incidental findings
- Overweight and obese participants:
- Body mass index (BMI) between 28 and 39.5 kg/m2
- Age between 20 to 65 years of age
- Waist circumference \> 80 cm for women, \> 94 cm for men
- Sex and age matched normal weight individuals:
- Body mass index (BMI) between 19.5 and 24.5 kg/m2
- Age between 20 to 65 years of age
Exclusion
- Insufficient knowledge of the German language
- Persons who cannot legally give consent
- Pregnancy or lactation
- History of severe mental or somatic disorders including neurological diseases (incl. Epileptic seizures)
- Taking psychotropic drugs
- Previous bariatric surgery
- Acute infection within the last 4 weeks
- Hemoglobin values less than 12g/dl for women, less than 14 g/dl for men
- Current participation in a lifestyle intervention study or a pharmaceutical study
- Contradictions to a MRI measurement (e.g. metal implants)
Key Trial Info
Start Date :
November 8 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05228067
Start Date
November 8 2021
End Date
December 31 2025
Last Update
March 30 2025
Active Locations (1)
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1
University Clinic Tübingen
Tübingen, Germany, 72076