Status:
RECRUITING
Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules
Lead Sponsor:
City of Hope Medical Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Thyroid Gland Carcinoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. T...
Detailed Description
PRIMARY OBJECTIVE: I. To evaluate the effect of Diagnostic DNA Methylation Signatures (DDMS-2) results (positive predictive value \[PPV\], negative predictive value \[NPV\], sensitivity and specifici...
Eligibility Criteria
Inclusion
- Patients without impaired decision-making capacity and who are undergoing needle biopsies for thyroid nodule diagnosis
- Over the age of 18
- Any gender, race and ethnicity
- Patients must provide informed consent prior to use of their tissues and clinical data
Exclusion
- Children are excluded from the study, since the biology of children thyroid nodules is different from adults
Key Trial Info
Start Date :
October 22 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 22 2026
Estimated Enrollment :
1450 Patients enrolled
Trial Details
Trial ID
NCT05229341
Start Date
October 22 2021
End Date
October 22 2026
Last Update
February 18 2025
Active Locations (1)
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1
City of Hope Medical Center
Duarte, California, United States, 91010