Status:
UNKNOWN
Sex-specific Differences in the Stress Response to Abdominal Aortic Aneurysm Repair
Lead Sponsor:
Imperial College London
Conditions:
Abdominal Aortic Aneurysm
Stress
Eligibility:
All Genders
50-100 years
Brief Summary
It is recognised that women are at greater risk of death, complications and longer hospital stay following intact abdominal aortic aneurysm (AAA) repair, and the reason for this is not yet established...
Eligibility Criteria
Inclusion
- Men and women undergoing primary elective intact AAA repair, open or endovascular (EVAR) at participating centres.
- Capacity to consent.
Exclusion
- Participants undergoing a secondary or emergency aortic procedure, or procedure for alternative aortic pathology.
- Relevant confounding pathology such as hypothalamic-pituitary axis pathology (e.g. Addison's disease).
- Lack of capacity to consent.
- Participants with pacemaker dependency, or a significant arrhythmia, will be excluded from analysis of heart rate variability, but will be included in the study for analysis of psychological and biochemical markers of stress.
- Participants on steroid treatment will also be excluded from analysis of biochemical markers but may be included for analysis of physiological markers and/or heart rate variability.
- Participants must be over the age of 50 (In order to facilitate capture of degenerative aortic aneurysmal pathology rather than an alternative aortic pathology e.g. traumatic, connective tissue disorder).
Key Trial Info
Start Date :
February 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05230264
Start Date
February 1 2022
End Date
October 1 2023
Last Update
February 8 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Imperial College London
London, United Kingdom