Status:
RECRUITING
Ex VIvo DEtermiNed Cancer Therapy
Lead Sponsor:
Sheffield Teaching Hospitals NHS Foundation Trust
Collaborating Sponsors:
University of Sheffield
Conditions:
Bladder Cancer
Kidney Cancer
Eligibility:
All Genders
16+ years
Brief Summary
EVIDENT's aim is to test if ex vivo drug screening can predict whether patients with solid cancers will respond, or not respond, to standard care treatments. Patients undergoing standard care surgery ...
Detailed Description
The EVIDENT study is a feasibility / proof of concept study which is designed to determine if ex vivo screening of a patient's solid tumour can predict the effectiveness of standard cytotoxic chemothe...
Eligibility Criteria
Inclusion
- \>16 years of age with a diagnosis of known or suspected solid cancer who will undergo surgery, biopsy, aspirate, or TURBT
- Willing to donate a section fresh tumour tissue from surgery, a TURBT, fluid aspirate, or biopsy surplus to diagnostic use
- Willing to donate a 9ml blood sample
- Able to give written informed consent
- Previously treated patients are eligible if:
- Present with a recurrence of a previously treated tumour. This may be a local or metastatic recurrence
- Have undergone treatment for their cancer, but fail to respond to this and progress
- Have received neoadjuvant therapy for their tumour
- Have undergone chemotherapy, targeted therapy, immunotherapy, hormone therapy and or radiotherapy for a previous tumour
Exclusion
- Patients with a known diagnosis of a blood borne virus (Hepatitis B, Hepatitis C, HIV). (The laboratories where experiments will be conducted do not have the safety facilities to use material containing these pathogens)
- Patients with a current positive COVID-19 infection
Key Trial Info
Start Date :
July 7 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT05231655
Start Date
July 7 2021
End Date
January 1 2027
Last Update
February 24 2025
Active Locations (1)
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1
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, South Yorkshire, United Kingdom, S10 2JF