Status:
RECRUITING
Intake of Nitrate-rich Vegetables and Their Effect on Inflammatory Molecules and Oral Microbiota of Patients With Periodontitis
Lead Sponsor:
University of Guadalajara
Conditions:
Periodontal Diseases
Periodontitis
Eligibility:
All Genders
30-65 years
Phase:
NA
Brief Summary
Vegetables, mainly green leafy ones and some others like beets, are a rich source of nitrate. Nitrate metabolism has shown benefits to the body and there are recent studies that agree that the consump...
Detailed Description
Background. Periodontitis (PD) is a chronic, multifactorial and inflammatory disease caused by the imbalance resulting from the proliferation of certain pathogenic bacteria that alter the symbiotic co...
Eligibility Criteria
Inclusion
- Men and/or women from 30 to 65 years old
- Voluntary participation and signing the written informed consent
- Not receiving nutritional treatment at the time of uptake
- Availability to attend all scheduled visits
- Have an indication to receive nonsurgical periodontal treatment (NSPT)
- Interdental clinical insertion loss ≥3mm and ≥5mm in the buccal or oral area of two or more non-adjacent teeth
- Detectable depths ≥ 5mm in two or more teeth
- Radiographic evidence of periodontal bone loss
Exclusion
- Trauma-Induced Gingival Recessions
- Cervical caries
- History of bleeding diathesis
- Pregnant or nursing women
- BMI \<18.5 kg / m2
- History of any of the following self-reported diseases: type 2 diabetes mellitus, high blood pressure, kidney or liver disease, inflammatory bowel diseases, autoimmune diseases and/ or use of medications to control these diseases.
- Having or presenting a high risk of infection by tuberculosis, hepatitis B or Human Immunodeficiency Virus (HIV)
- Use of antibiotics (including antibiotic oral rinse) 6 months prior to or during the study
- Having received specialized periodontal treatment in the previous 6 months.
- Smoking habit
- Require an interpreter or not understand Spanish to attend or provide written material.
Key Trial Info
Start Date :
June 23 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05232331
Start Date
June 23 2021
End Date
December 31 2025
Last Update
August 16 2024
Active Locations (1)
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1
Integral Dental Clinics CUCS UDG
Guadalajara, Jalisco, Mexico, 44340