Status:
COMPLETED
Validation of 3-[11C]-OHB
Lead Sponsor:
University of Aarhus
Conditions:
Diabetes Mellitus, Type 2
Heart Failure
Eligibility:
All Genders
50-70 years
Phase:
NA
Brief Summary
Ketone bodies are produced in the liver at high levels of fatty acids, and act as an important source of energy for the brain and heart during fasting. The energy production from ketone metabolism is ...
Detailed Description
Background: Ketone bodies consists of 3-hydroxybutyrat, acetoacetate, and acetone. They are produced in the liver at high levels of fatty acids, and act as an important source of energy for the heart...
Eligibility Criteria
Inclusion
- Age between 50-70 years
- BMI: 20-30 kg/m\^2
Exclusion
- All drugs that could affect the outcome
- HbA1c \> 48 mmol/mol
- Known heart failure og episodes of acute myocardial infarction
- Liver disease ALAT \> higher than 3 times of the normal level
- Kidney disease eGFR \< 60 ml/min
- Blood donation in the last 3 months before inclusion
- Participation in other studies with radiation in the last 6 months
- Alcohol addiction
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 29 2023
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT05232812
Start Date
June 1 2022
End Date
March 29 2023
Last Update
March 31 2023
Active Locations (1)
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1
Aarhus University Hospital
Aarhus N, Jutland, Denmark, 8200