Status:
UNKNOWN
Circulating Biomarkers in Patients With Anal Cancer Treated With Induction Chemotherapy
Lead Sponsor:
Aarhus University Hospital
Conditions:
Anal Cancer
Locally Advanced Squamous Cell Carcinoma
Eligibility:
All Genders
18+ years
Brief Summary
To investigate the prognostic and predictive value of plasma HPV (pHPV) prior, during and after induction chemotherapy (ICT) in locally advanced squamous cell carcinoma of the anus (SCCA) or synchrono...
Detailed Description
Anal cancer is a rare malignancy with approximately 200 new cases in Denmark per year, and the standard treatment is chemoradiotherapy (CRT). The treatment is centralised at three oncological departme...
Eligibility Criteria
Inclusion
- Histological verified squamous cell carcinoma of the anus
- Treatment with ICT prior to definitive CRT or RT due to locally advanced disease or
- Patients with synchronous metastatic disease treated with ICT with the purpose of definitive CRT (potentially in combination with organ directed therapy (surgery, RFA, SBRT) for the metastatic sites)
- Age ≥ 18 years
- Written and orally informed consent
Exclusion
- Contraindications for blood sampling
- Other malignancy within the past five years, with exception of basal cell carcinoma
Key Trial Info
Start Date :
January 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05233540
Start Date
January 1 2022
End Date
December 1 2025
Last Update
February 10 2022
Active Locations (3)
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1
Department of Oncology, Aarhus University Hospital
Aarhus, Aarhus N, Denmark, 8200
2
Department of Oncology Herlev and Gentofte Hospital
Herlev, Denmark, 2730
3
Department of Oncology, Vejle hospital, University Hospital of Southern Denmark
Vejle, Denmark, 7100