Status:
COMPLETED
The Effect of Ovotransferrin and Lactoferrin on Iron Absorption From Ferrous Sulfate in Adult Women
Lead Sponsor:
Swiss Federal Institute of Technology
Conditions:
Iron-deficiency
Eligibility:
FEMALE
18-45 years
Phase:
NA
Brief Summary
OTf is a monomeric glycoprotein of 686 amino acid residues and, as a member of the transferrin family, folds into two homologous globular lobes, each containing a single reversible Fe3 + binding site ...
Detailed Description
Iron deficiency remains a major public health problem in both developed and developing countries. At present, iron deficiency is mostly combated with iron supplements in the form of iron salts, especi...
Eligibility Criteria
Inclusion
- female aged between 18-45 years old;
- SF \<25 µg / L;
- BMI 18.5-24.9 kg / m2;
- weight \<70 kg;
- signed informed consent;
- Able to communicate and comprehend English language.
Exclusion
- Anemic (Hb \<12 g / dL);
- inflammation (CRP\> 5 mg / L);
- chronic digestive, renal and / or metabolic disease;
- chronic medications (except for oral contraceptives);
- use of vitamin, mineral and pre- and / or probiotic supplements in the previous 2 weeks and during the course of the study;
- blood transfusion, blood donation or significant blood loss over the past 4 months;
- difficulties with blood sampling;
- antibiotic treatment in the previous 4 weeks before the start of the study and during the course of the study;
- known hypersensitivity to egg;
- pregnancy (tested in serum at screening) or intention to become pregnant during the course of the study;
- lactation up to 6 weeks before study initiation;
Key Trial Info
Start Date :
April 25 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 20 2022
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT05233709
Start Date
April 25 2022
End Date
May 20 2022
Last Update
June 10 2022
Active Locations (1)
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1
ETH Zurich, Laboratory of Human Nutrition
Zurich, Switzerland, 8092