Status:

UNKNOWN

Personalized Immune Cell Therapy Targeting Neoantigen of Malignant Solid Tumors

Lead Sponsor:

Sichuan University

Conditions:

Carcinoma

Melanoma

Eligibility:

All Genders

18-75 years

Phase:

PHASE1

Brief Summary

This single center, single arm and prospective study aimed to establish gene mutation database and select the neoantigens in patients with advanced malignant melanoma, bladder cancer and colorectal ca...

Eligibility Criteria

Inclusion

  • Age:18-75 years
  • Pathologically diagnosed advanced (stage IV) malignant melanoma, bladder cancer or colorectal cancer with measurable lesions;
  • Failed in the previous standard therapy;
  • ECOG PS (Eastern Cooperative Oncology Group performance status) score 0-2 points;
  • The estimated survival period is ≥3 months;
  • Rehabilitate from previous therapy;
  • Adequate organ functions;
  • Patient's written informed consent;

Exclusion

  • Tumor emergencies;
  • Abnormal coagulation function;
  • Contagious diseases, such as HIV, HBV, HCV infection;
  • Mental disorders;
  • Concomitant tumors;
  • Immunological co-morbidities

Key Trial Info

Start Date :

March 1 2022

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 2 2023

Estimated Enrollment :

60 Patients enrolled

Trial Details

Trial ID

NCT05235607

Start Date

March 1 2022

End Date

December 2 2023

Last Update

February 11 2022

Active Locations (1)

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Page 1 of 1 (1 locations)

1

West China Hospital

Chengdu, Sichuan, China, 610000