Status:
RECRUITING
Neuromuscular Fatigue During Exercise in COPD-HF Overlap
Lead Sponsor:
University Hospital, Grenoble
Conditions:
Pulmonary Disease, Chronic Obstructive
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Rationale. Chronic obstructive pulmonary disease (COPD) and heart failure (HF) coexist in approximately one third of patients presenting with one of these conditions. From a clinical standpoint, impai...
Eligibility Criteria
Inclusion
- Age ≥ 18 years;
- COPD: mild-to-severe airflow obstruction (forced expiratory volume in 1 second (FEV1)/forced vital capacity ratio \<0.70; post-bronchodilator FEV1 \> 30% predicted);
- HF: reduced left ventricular ejection fraction (\<50%, for COPD-HF patients only);
- HF: New York Heart Association Functional Classification I to III (for COPD-HF patients only);
- Clinical stability for both diseases (COPD and/or HF) and no recent (within 3 months) exacerbation requiring a change in medications;
- Patient benefiting from health care coverage;
- Patient able to provide written informed consent.
Exclusion
- Inability to perform cycle ergometry;
- Medical device incompatible with magnetic stimulation;
- Counter-indication to perform exercise test;
- Patient refusing to sign written informed consent;
- Patient not benefiting from health care coverage;
- Patient exceeding the annual ceiling of authorized compensation received following participation to a clinical trial;
- Patient deprived of freedom by judicial or administrative decision;
- Patient subject to a measure of legal protection (safeguard of justice, guardianship, curatorship), who cannot be included in clinical trials;
- Pregnant or nursing woman.
Key Trial Info
Start Date :
February 21 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05235685
Start Date
February 21 2023
End Date
December 1 2025
Last Update
June 24 2024
Active Locations (1)
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1
CHU Grenoble Alpes - Hopital Sud (Laboratoire HP2)
Échirolles, Auvergne-Rhône-Alpes, France, 38130