Status:
COMPLETED
Study of Vascular Endothelial Glycocalyx and Ophthalmic Injury, Prospective Cohort of Patients With Prolonged Post-COVID-19 Symptoms
Lead Sponsor:
Fondation Ophtalmologique Adolphe de Rothschild
Conditions:
COVID-19
Long COVID
Eligibility:
All Genders
18+ years
Brief Summary
The glycocalyx is a membrane coat composed of glycoproteins attached to the surface of cell membranes. Recent publications have drawn attention to the potential role of a degradation of the endothelia...
Detailed Description
The aim of this study is to extend the exploration of the microvascular system by a microscopic imaging technique of sublingual blood capillaries. The GlycoCheck is a medical device with CE marking. I...
Eligibility Criteria
Inclusion
- Diagnosis of long COVID, namely:
- Initial symptomatic episode of COVID-19: Either confirmed by at least one of the following criteria: Positive SARS-Cov-2 PCR (polymerase chain reaction, positive SARS-CoV-2 antigenic test, prolonged anosmia/ageusia of abrupt onset, typical chest CT (computerized tomography) scan (bilateral ground glass pneumonia...), or probable by the association of at least 3 criteria, of sudden onset, in an epidemic context, among: fever, headache, fatigue, myalgia, dyspnea, cough, chest pain, diarrhea, odynophagia. A positive SARS-CoV-2 serology may help in this diagnosis.
- Presence of at least one of the initial symptoms beyond 4 weeks after the onset of the acute phase of the disease
- Initial and prolonged symptoms not explained by another diagnosis with no known relationship to COVID-19
- Referred for ophthalmologic evaluation to the Rothschild Foundation Hospital
- Expressed consent to participate in the study
Exclusion
- Pregnant or breastfeeding woman
- Known allergy to indocyanine green
Key Trial Info
Start Date :
February 10 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2022
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT05235698
Start Date
February 10 2022
End Date
June 1 2022
Last Update
July 1 2022
Active Locations (1)
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1
Hospital-Foundation Adolphe de Rothschild
Paris, France, 75019