Status:
RECRUITING
Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc
Lead Sponsor:
University of California, Davis
Collaborating Sponsors:
National Cattlemen's Beef Association, a contractor to the Beef Checkoff
Conditions:
Zinc Deficiency
Inflammation
Eligibility:
All Genders
55-70 years
Phase:
NA
Brief Summary
The objective of the current study is to test the overarching hypothesis that the beef nutritive matrix is uniquely suited to direct dietary zinc to cellular compartments for improved metabolic functi...
Detailed Description
This study will examine whether daily beef intake will promote the absorption of dietary zinc into cells, leading to improved cellular zinc status and microvascular function. The study design will be ...
Eligibility Criteria
Inclusion
- Male or postmenopausal female 55-70 years of age
- Women: lack of menses for at least two years.
- Subject is willing and able to comply with the study protocols.
- Subject is willing to participate in all study procedures
- Self-reported stable dose of prescribed medications for a minimum of 6 months
- BMI 18.5 - 29.9 kg/m2
Exclusion
- Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
- Prescribed metaformin, statins or medications known to interfere with zinc, protein, or lipid metabolism
- Vegan, Vegetarians, food faddists or those consuming a non-traditional diet (e.g. Adkins, Keto, Paleo, etc.)
- Fruit consumption ≥ 3 cups/day
- Regular consumption of strawberries (2-3 servings/week)
- Vegetable consumption ≥ 4 cups/day
- Coffee/tea ≥ 3 cups/day
- Dark chocolate ≥ 3 oz/day
- Alcohol intake greater than 2 drinks in a day for men, or 1 drink in a day for women.
- Self-reported restriction of physical activity due to a chronic health condition
- Self-reported chronic/routine high intensity exercise
- Self-reported diabetes
- Blood pressure ≥ 140/90 mm Hg
- Self-reported renal or liver disease
- Self-reported heart disease, which includes cardiovascular events and stroke
- Peripheral artery disease Raynaud's syndrome or disease
- Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT
- Self-reported cancer within past 5 years
- Self-reported malabsorption
- Unwillingness to stop any supplement use six weeks prior to study initiation, including multivitamin/mineral, powders, herbal, plant or botanical, pro- and prebiotics, and oil supplements.
- Smoking, vaping, cannabis use
- Current enrollee in a clinical research study.
Key Trial Info
Start Date :
October 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05236374
Start Date
October 1 2022
End Date
December 31 2026
Last Update
December 5 2025
Active Locations (1)
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1
University of California, Davis; Department of Nutrition
Davis, California, United States, 95616