Status:
UNKNOWN
(Phosphodiesterase 5 Inhibitors & α-blockers): Single Versus Combined Therapy in Benign Prostatic Hyperplasia
Lead Sponsor:
Assiut University
Conditions:
Benign Prostatic Hyperplasia
Eligibility:
MALE
45-75 years
Phase:
NA
Brief Summary
To compare between efficacy of phosphodiesterase5 inhibitors (tadalafil 5 mg) and Alpha Blockers (tamsulosin 0.4 mg) monotherapy vs combined therapy in treatment of lower urinary tract symptoms of ben...
Detailed Description
The proposed research aims to answer the question about efficacy and safety of phosphodiesterase 5 inhibitors (tadalafil 5 mg) and Alpha Blockers (tamsulosin 0.4 mg) monotherapy vs combined therapy in...
Eligibility Criteria
Inclusion
- 1 - Men \> 45 years with LUTS/BPH for \> 6 months 2- IPSS of ≥ 8 and Qmax of ≥ 4 to≤ 15 mL/s
Exclusion
- PSA level of \> 10.0 ng/mL (if ≥ 4.0 to≤ 10.0 ng/mL prostate cancer will be excluded).
- Post-voidresidual urine volume of ≥ 150 mL.
- Previous Urine Retention or Urethral Catheterization .
- other pathology such as urinary bladder stone , bladder mass or neurogenic bladder .
- Any case of LUTS other than BPH (urinary bladder stone, neurogenic bladder, bladder neck contracture,rethral stricture, bladder cancer, acute or chronic prostatitis, acute or chronic urinary tract infection).
- patients supposed to undergo intraocular operation (as cataract operation) .
- History of head injury or cerebrovascular stroke or spinal injury.
- pelvic fracture.
- Uncontrolled diabetic patient.
- Patients with chronic obstructive lung disease on medical treatment.
- Parasympatholytic drugs are contraindicated during the study. 12. Patients refusing to share in the study.
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2024
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT05236634
Start Date
May 1 2022
End Date
June 30 2024
Last Update
February 11 2022
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.