Status:
ACTIVE_NOT_RECRUITING
Treatment of Advanced Grade III Periodontal Furcation Lesions
Lead Sponsor:
King's College London
Conditions:
Furcation Defects
Periodontitis
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Periodontitis, a microbially-driven inflammatory disease has been shown to be the sixth most common disease of mankind. The 2009 UK Adult Dental Health Survey found that 54% of adults experience gum b...
Detailed Description
Study teeth will have received at least one course of non-surgical periodontal treatment (NSPT) prior inclusion to the trial. At the baseline appointment participants will be randomly assigned to a tr...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- The following criteria will be considered for inclusion in the study:
- Age 18-70
- Diagnosis of Periodontitis stage III or IV, grade A, B or C
- At least one maxillary or mandibular molars with:
- Furcation involvement grade III horizontal classification degree B-C vertical classification without any ongoing restorative problems as judged by the study clinician)
- Probing depth ≥ 6mm
- Mobility \< degree II (as examined by the study clinician)
- Absence of any ongoing endodontic pathology (as examined by the study clinician)
- Absence of an adjacent tooth with unfavorable periodontal prognosis (as judged by the study clinician)
- Non-surgical periodontal therapy performed to the study site within the last 6 months.
- Able to consent to study participation
- Exclusion Criteria
- Smoking (any current or in past 5 years)
- Medical history including diabetes or hepatic or renal disease, or other serious medical conditions or transmittable diseases
- History of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures
- Anti-inflammatory or anticoagulant therapy during the month preceding the baseline exam
- Systemic antibiotic therapy during the 3 months preceding the baseline exam
- History of alcohol or drug abuse
- •. Self-reported pregnancy or lactation
- Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that according to the investigator may increase the risk associated with trial participation
- Previous surgical periodontal performed to the study site.
Exclusion
Key Trial Info
Start Date :
February 5 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05237739
Start Date
February 5 2022
End Date
March 1 2024
Last Update
February 6 2024
Active Locations (1)
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1
King's College London
London, United Kingdom