Status:
UNKNOWN
Effect of Magnesium on Remifentanil Induced Cough
Lead Sponsor:
Seoul National University Bundang Hospital
Conditions:
Cough
Eligibility:
All Genders
20-75 years
Phase:
PHASE4
Brief Summary
The hypothesis of this study is that Magnesium sulfate pretreatment (50mg/kg) will reduce the incidence of cough and chest wall rigidity caused by remifentanil administration. The purpose of this stu...
Eligibility Criteria
Inclusion
- Patients aged 20-75 years of age who are undergoing surgery under general anesthesia using a laryngeal mask and who have consented to participate in this study among American Society of Anesthesiologists body grade 1 or 2
Exclusion
- When coughing may occur due to an underlying disease (upper respiratory infection, rhinitis, post nasal drip, asthma, chronic obstructive pulmonary disease, pneumonia, bronchitis, current smokers, etc.)
- If you have kidney disease that can affect magnesium metabolism (glomerular filtration rate less than 60)
- If you are taking opioid analgesics or magnesium for other reasons
- Patients with hypermagnesemia
- Patients with atrioventricular block (stages I-III) or other cardiac conduction disorders
- Pregnant or lactating women
- Patients with myasthenia gravis
- Patients taking drugs that are contraindicated or interact with magnesium (barbitalates, aminoglycoside antibiotics, isoniazid, chlorpromazine, digoxin)
- In case of hypersensitivity to magnesium
- Patients with a history of hypersensitivity to propofol and any of its components
- Patients with a history of hypersensitivity to remifentanil and other fentanyl analogues
Key Trial Info
Start Date :
February 3 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2022
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT05237791
Start Date
February 3 2022
End Date
December 30 2022
Last Update
February 14 2022
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