Status:
UNKNOWN
The Effect of Gluten-free Diet on Parkinsonism
Lead Sponsor:
General University Hospital, Prague
Collaborating Sponsors:
Czech Academy of Sciences
Conditions:
Parkinson Disease
Multiple System Atrophy
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
Recent data suggest that the brain-gut axis, chronic intestinal inflammation and microbiome may contribute to the pathogenesis of neurodegenerative diseases with alfa-synucleinopathy, which include Pa...
Detailed Description
This project is based on two research lines, testing the effect of gluten-free diet in a patients with PD and MSA (a human prospective trial) and in the chronic MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahy...
Eligibility Criteria
Inclusion
- subjects with establish diagnosis of PD in clinical stage 2-4 of Hoehn\&Yahr scale or with establish diagnosis of MSA
- stable treatment for \>4 weeks
- willing and able to give informed consent for participation in the study
- male and female subjects, aged 40 years or older
- able to understand and willing to comply with study procedures
- willing to avoid any other diet restrictions
- BMI 18-30
Exclusion
- concomitant neurological, gastrointestinal or immunological disease
- diet restriction
- dementia affecting compliance
- acute psychiatric symptoms
Key Trial Info
Start Date :
October 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT05238545
Start Date
October 1 2021
End Date
December 31 2025
Last Update
April 8 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
GUHPrague
Prague, Czechia