Status:
COMPLETED
A Randomized Trial of NSAID Dosing Strategies
Lead Sponsor:
Montefiore Medical Center
Conditions:
Musculoskeletal Pain
Acute Pain
Eligibility:
All Genders
18-69 years
Phase:
PHASE4
Brief Summary
This study will compare the efficacy of two different non-steroidal anti-inflammatory drugs (NSAIDs) ketorolac and ibuprofen for people with acute moderate or severe musculoskeletal pain. The investig...
Eligibility Criteria
Inclusion
- Acute musculoskeletal pain: Any pain attributable to muscles, bones, joints, tendons, ligaments or supporting structures, as determined by the clinical team, of 10 days duration or less. Prior to the onset of acute pain, patients cannot have experienced pain in the same body region during the prior six months
- Pain has to be described as moderate or severe, when the patient is asked if the pain is mild, moderate or severe in intensity
Exclusion
- Contraindication to NSAIDs (allergy to NSAID or allergy to aspirin without history of tolerating NSAIDs, history of gastrointestinal bleeding, daily medication for gastritis or PUD, chronic kidney disease 2-5, heart failure)
- Contraindication to acetaminophen (hepatitis or cirrhosis)
- Use of an NSAID within the previous eight hours
- Use of acetaminophen within the previous eight hours
- Chronic pain, defined as any pain on \>50% of days for at least 3 months prior to onset of acute pain
- Recurrent pain in the same body part as the presenting complaint
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 24 2023
Estimated Enrollment :
407 Patients enrolled
Trial Details
Trial ID
NCT05239767
Start Date
June 1 2022
End Date
April 24 2023
Last Update
August 15 2023
Active Locations (1)
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1
Montefiore
The Bronx, New York, United States, 10467