Status:
RECRUITING
Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Collaborating Sponsors:
University of California, Davis
National Institute of Mental Health (NIMH)
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Novel invasive neurostimulation stimulation strategies through neurosurgical interventions are emerging as a promising therapeutical strategy for major depressive disorder. These have been applied mos...
Detailed Description
Participants (n=24) will complete a decision-making task in which participants will make decisions under uncertainty and seek to maximize rewards. The researchers will assess behavioral (risk attitude...
Eligibility Criteria
Inclusion
- \- The study will follow clinical criteria for epilepsy patient recruitment for invasive monitoring. As a results, individuals of adults of all ages are expected to be included in this study.
Exclusion
- Adults over 80 years of age will be excluded as per concerns of cognitive decline.
- Children under 18 will be excluded from the study since the maturation of frontal lobes continues through adolescence and significant differences in frontal lobe functioning between children younger than 18 and adults are often observed.
Key Trial Info
Start Date :
October 6 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2027
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT05239780
Start Date
October 6 2021
End Date
August 31 2027
Last Update
September 25 2025
Active Locations (1)
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1
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 100119