Status:
RECRUITING
Evaluation of the Impact of Taking American Ginseng for 8 Weeks on Fatigue in Patients Treated for Localized Breast or Gynecological Cancer
Lead Sponsor:
Centre Francois Baclesse
Collaborating Sponsors:
NATSUCA laboratory
Groupement Interrégional de Recherche Clinique et d'Innovation
Conditions:
Breast Cancer
Fatigue
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
This is a multicenter randomized trial in breast cancer patients reporting cancer-related fatigue to evaluate the efficacy and safety of Qiseng® based on extract of American ginseng combined with vita...
Eligibility Criteria
Inclusion
- Patients with localized breast or gynecological cancer treated as curative adjuvant and/or neoadjuvant chemotherapy and/or adjuvant radiotherapy. These treatments must have been completed within 6 months of inclusion.
- Patient reporting a chronic, stable fatigue state at investigator assessment, defined as a fatigue score ≥ 4 on the visual analog scale rated up to 10, experienced for at least one month
- Maintenance therapy with hormone therapy or other maintenance therapy (trastuzumab, bevacizumab…) is allowed before and/or during the study (except for pembrolizumab, abemaciclib and PARP inhibitors, which are not authorized)
- Patient 18 years of age or older
- Effective contraception in women of childbearing age
- Patient affiliated to a social security plan
- Signed informed consent
Exclusion
- Other identified causes of fatigue (anemia of grade \> 2, underlying chronic disease known to be associated with fatigue)
- Ongoing chemotherapy (patients scheduled for oral capecitabine or trastuzumab-emtasin in the adjuvant setting are not eligible)
- Metastatic breast or gynecological cancer
- Ongoing treatment with a tyrosine kinase inhibitor or other P-gp transported molecule or Pembrolizumab or PARP inhibitors
- Patient requiring oral diabetes therapy
- Regular intake of Vitamin C (in addition to what is provided by the diet)
- Patients with chronic pain requiring daily treatment with analgesics, anti-inflammatory drugs or corticosteroids
- Consumption of ginseng-based products in the month prior to inclusion
- Hypersensitivity to any of the components of Qiseng or placebo
- Pregnant or breastfeeding patient
- Simultaneous participation in another therapeutic clinical trial (trial using an experimental product)
- Patient deprived of liberty, under guardianship or curatorship
- Patient unable to undergo the medical follow-up of the trial for geographical, social or psychopathological reasons
- History of any other malignant disease during the last 3 years, except for skin cancer other than melanoma, carcinoma in situ of the uterus. Any other solid tumor or lymphoma (without bone marrow involvement) must have been treated and show no signs of recurrence for at least 3 years
Key Trial Info
Start Date :
September 27 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
354 Patients enrolled
Trial Details
Trial ID
NCT05241405
Start Date
September 27 2022
End Date
September 1 2027
Last Update
October 1 2024
Active Locations (10)
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1
ARCOCEA_Clinique Europe
Amiens, France
2
Ch Bayeux
Bayeux, France
3
Centre Pierre Curie
Beuvry, France
4
Centre François Baclesse
Caen, France