Status:
UNKNOWN
Cardiorenal Effecs of Losartan in Kidney Transplant Recipients
Lead Sponsor:
Medical University of Gdansk
Collaborating Sponsors:
Medical University of Warsaw
Pomeranian Medical University Szczecin
Conditions:
Renal Transplant Failure
Cardiovascular Complication
Eligibility:
All Genders
18-65 years
Brief Summary
The influence of Losartan to cardiovascular and renal outcomes in patients after renal transplatation.
Detailed Description
The benefits of cardio and nephroprotective properties of treatment with drugs blocking the renin angiotensin aldosterone system in the general population has already been shown. There are no data on ...
Eligibility Criteria
Inclusion
- 740 patients, either sex, either non-diabetic or diabetic who underwent the kidney transplantation and who:
- Are at least three months post-transplantation
- Have hypertension.
- Have an estimated glomerular filtration rate greater than or equal to 30 ml/min/1.73 m2
Exclusion
- Pregnant or the possibility of becoming so and breast feeding.
- Angioedema from an Angiotensin Converting Enzyme (ACE) inhibitor or Angiotensin Receptor Blocker (ARB) in the history.
- Serum potassium greater than 5.5 mmol/l on two or more occasions in the preceding three months.
- Graft artery stenosis (i.e. psv of more than 200 cm/s in doppler usg)
- Left ventricular dysfunction that requires an ACE inhibitor or an ARB
- New immunosuppressive agent was started or previous immunosuppressant stopped in the three months prior to study entry or plan to switch immunosuppressive agents within next three months.
- Currently on four or more blood pressure pills and have an average blood pressure over three visits greater than 150/100.
- Currently on an ACE-inhibitor or an ARB or treatment with an ACE inhibitor or ARB after kidney transplantation lasted more than 3 months.
- Had an acute coronary syndrome, episode of malignant hypertension, stroke or transient ischaemic attack in the three months prior to study entry.
Key Trial Info
Start Date :
September 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
740 Patients enrolled
Trial Details
Trial ID
NCT05243446
Start Date
September 1 2015
End Date
December 31 2023
Last Update
February 17 2022
Active Locations (1)
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1
Medical University
Gdansk, Poland, 80-952