Status:
COMPLETED
Trial to Study the Effect of CVL-231 on 24-Hour Ambulatory Blood Pressure in Participants With Schizophrenia
Lead Sponsor:
Cerevel Therapeutics, LLC
Conditions:
Blood Pressure
Schizophrenia
Eligibility:
All Genders
30-60 years
Phase:
PHASE1
Brief Summary
The purpose of this trial is to characterize the effects of 2 oral doses (over 8 weeks total) of CVL-231 on ambulatory blood pressure and heart rate in patients with stable schizophrenia.
Eligibility Criteria
Inclusion
- Male and female participants, ages 30 to 60 years, inclusive, at the time of signing the ICF.
- Primary diagnosis of schizophrenia per DSM-5, as confirmed by the MINI version 7.0.2.
- PANSS Total Score ≤70 at the time of signing the ICF and Check-in (Day -5).
Exclusion
- Current DSM-5 diagnosis other than schizophrenia including, but not limited to, mental retardation; schizoaffective disorder; major depressive disorder; schizophreniform disorder; psychotic depression; bipolar disorder; post-traumatic stress disorder; generalized anxiety disorder, obsessive compulsive disorder, eating disorders (bulimia, anorexia), or other anxiety disorders as a primary diagnosis (Note: Anxiety symptoms secondary to schizophrenia are allowed); delirium, dementia, amnestic, or other cognitive disorders. Acute depressive symptoms within 30 days prior to signing the ICF that require treatment with an antidepressant are exclusory. Additional excluded conditions include borderline, paranoid, histrionic, schizotypal, schizoid, or antisocial personality disorder.
- Any of the following:
- Schizophrenia considered resistant/refractory (defined as failure to respond to 2 or more courses of adequate pharmacological treatment) to antipsychotic treatment by history
- History of failure to respond to clozapine
- Response to clozapine treatment only
- History of extrapyramidal symptoms treated with a medication that required dose modification and/or new treatment within 6 months prior to signing the ICF.
- Current or past history of significant cardiovascular disease including any of the following: ischemic heart disease, myocardial infarction, cardiac valvulopathy, cardiac surgery revascularization (coronary artery bypass grafting) or stenting or percutaneous transluminal coronary angioplasty), hypertension, receiving medications to treat hypertension, orthostatic hypotension, angina, unstable angina, cerebrovascular accident or stroke or transient ischemic attack, pacemaker, atrial fibrillation, atrial flutter, paroxysmal atrial tachycardia, or non-sustained or sustained ventricular tachycardia, pulmonary arterial hypertension, sick sinus syndrome, Type 2 second-degree or third-degree atrioventricular block, congestive heart failure, personal or family history of sudden death or long QT syndrome, unexplained syncope or syncope within the last 3 years regardless of etiology.
- 12-lead ECG demonstrating any of the following at the Screening Visit or at Check-in (Day -5):
- QTcF interval \>450 ms
- QRS interval \>120 ms (unless right bundle branch block)
- PR interval \>200 ms
- LVH with ST depressions and/or T wave inversions in leads with relatively tall R waves (ie, LVH with associated ST-T wave abnormalities)
- Type 2 second-degree or third-degree atrioventricular block
- Heart rate \<45 bpm or \>90 bpm
- Abnormal acute ECG changes (such as clinically significant ST depression or elevation or T wave inversion)
- Abnormal heart rhythm (atrial fibrillation and atrial flutter)
- Blood pressure measurements demonstrating any of the following at the Screening Visit and at Check-in (Day -5):
- Systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg
- o Blood pressure will be measured in a seated position after at least 3 minutes of rest. The average of 3 measurements will be used to determine eligibility.
- Orthostatic hypotension, defined as a decrease of ≥20 mmHg in systolic blood pressure after at least 2 minutes of standing compared with the average of the resting supine blood pressure measurement
Key Trial Info
Start Date :
January 24 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 14 2022
Estimated Enrollment :
151 Patients enrolled
Trial Details
Trial ID
NCT05245539
Start Date
January 24 2022
End Date
November 14 2022
Last Update
December 14 2022
Active Locations (10)
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1
Pillar Clinical Research LLC
Bentonville, Arkansas, United States, 72712
2
Woodland International Research Group LLC - ERG - PPDS
Little Rock, Arkansas, United States, 72211
3
Collaborative NeuroScience Research, LLC - Torrance - Apex - PPDS
Long Beach, California, United States, 90806
4
Innovative Clinical Research, Inc - ClinEdge - PPDS
Miami, Florida, United States, 33016