Status:
RECRUITING
Pre- Vs. Postoperative Thromboprophylaxis in Pancreatic Surgery
Lead Sponsor:
Helsinki University Central Hospital
Conditions:
Pancreas Cancer
Pancreas Neoplasm
Eligibility:
All Genders
18-120 years
Phase:
PHASE4
Brief Summary
Thromboprophylaxis for pancreatic surgery can be commenced either preoperatively or postoperatively. Despite a clear trade-off between thrombosis and bleeding in pancreatic surgery patients, there is ...
Eligibility Criteria
Inclusion
- All patients undergoing either
- pancreaticoduodenectomy or total pancreatectomy (for any indication) or
- distal pancreatectomy for suspicion of cancer
Exclusion
- Patient on anticoagulative medication (heparin, low-molecular weight heparin, warfarin, direct oral anticoagulants) during the month (30 days) preceding surgery
- Emergency operation (e.g. for trauma, infection or pancreatitis)
- Age \< 18 years
- Allergy or other contraindication to planned low-molecular weight heparin
- Inability to give written informed consent
- Pancreatic resection not performed (removed from analyses after randomization)
Key Trial Info
Start Date :
August 17 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT05245877
Start Date
August 17 2022
End Date
September 1 2026
Last Update
February 14 2025
Active Locations (5)
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1
Sunnybrook Health Sciences Centre
Toronto, Canada
2
Helsinki University Hospital
Helsinki, Finland
3
Oulu University Hospital
Oulu, Finland
4
Tampere University Hospital
Tampere, Finland